In the world of biohacking and modern wellness, GLP-1 peptides are one of the hottest topics, particularly when it comes to overall longevity, metabolic health, appetite control, and weight management. Among these peptides, semaglutide has gained immense popularity. Thanks to its widespread real-world success and impressive clinical outcomes. However, this peptide is not the only GLP-1 option out there. Biohackers are comparing it with other peptides in the same family to decide which one fits their objectives the best.
You will be interested in understanding how semaglutide stacks up against its peers or what biohackers are really evaluating when selecting a GLP-1 peptide. From this blog post, you can gain insights into everything about this peptide.
GLP-1 Peptides – What Are They?
GLP-1 or glucagon-like peptide-1 is a hormone that is naturally produced in the human gut. It helps with the regulation of:
- Energy balance
- Gastric emptying
- Insulin secretion
- Blood sugar levels
- Appetite
GLP-1 receptor agonists or GLP-1 RAs are modified or synthetic peptides that mimic the effects of natural GLP-1. However, in a longer-lasting and more potent way. They are used widely in clinical settings for managing obesity and type 2 diabetes, and they have gained huge traction in the performance and wellness community for their ability to support metabolic improvement and weight loss.
Here are a few popular GLP-1 peptides:
- Exenatide
- Tirzepatide
- Dulaglutide
- Liraglutide
- Semaglutide
Every peptide interacts with the GLP-1 receptor differently. This is why the effects that users get from them vary.
Why Are Biohackers Interested in GLP-1 Peptides?
The biohacking community loves GLP-1 peptides due to the following benefits they bring:
- Improves energy by controlling fluctuations in glucose levels
- Helps with reducing systemic inflammation
- Stabilized blood sugar levels
- Improves metabolic flexibility
- Supports sustainable and steady fat loss
- Brings down cravings and appetite
However, many biohackers are combining GLP-peptides with longevity-focused supplementation, high-protein diets, keto, or fasting for the best results.
Semaglutide: The Most Familiar GLP-1 Peptide
In GLP-1 peptide comparisons, semaglutide has become a benchmark. It is popular for its long half-life and strong power to suppress appetite. Also, many describe its results as incomparable. Here are some factors that make this peptide stand out from the others available:
Very Long Half Life
Once taken, semaglutide lasts in the body for about a week. It means that it does not need frequent dosing, and using it once a week is sufficient.
Powerful Appetite Suppression
Many users have reported a considerable reduction in hunger pangs. Also, many users have expressed that after they started using these peptides, they have experienced fewer cravings. As a result, they have experienced consistent calorie reduction.
Considerable Weight-Loss Results
Over several months of usage, clinical studies have reported double-digit percentage of body weight reduction among users.
Metabolic Advantages
Semaglutide helps stabilize blood sugar levels. It is known to bring down inflammation, and users have experienced better insulin sensitivity.
Smooth Release Profile
Stable release of semaglutide into the bloodstream contributes to fewer dips and peaks and consistent effects.
Comparing Semaglutide with Other GLP-1 Peptides
Semaglutide Vs. Liraglutide
Liraglutide was the first GLP-1 Peptide. It was adopted widely for weight management. However, compared to semaglutide, it is considered less potent.
Key Differences
| Feature | Liraglutide | Semaglutide |
| Dosing Frequency | Daily | Weekly |
| Appetite Suppression | Moderate | Strong |
| Weight-loss potency | Good but slower | Higher |
| Half-life | -13 hours | -1 week |
What Do Biohackers Feel?
People who hate to take daily injections opt for semaglutide over liraglutide. Also, semaglutide is chosen by biohackers targeting more considerable transformation and stronger appetite suppression. Liraglutide is chosen by those looking for incremental or gentle weight loss.
Semaglutide Vs Dulaglutide
Similar to semaglutide, dulaglutide is also a weekly GLP-1 RA. However, it has different features compared to semaglutide.
Key Differences
| Features | Dulaglutide | Semaglutide |
| Molecular size | Larger protein-bound peptide | Small peptide |
| Typical weight loss | Modest | Considerable |
| Appetite effects | Mild | Strong |
| Potency | Moderate | Very high |
Biohackers’ Views
Dulaglutide is smoother. However, it may cause fewer gastrointestinal effects. When it comes to fat-loss efficiency, semaglutide is the winner between the two. Those looking for glucose control at times, experiment with dulaglutide.
Semaglutide Vs. Exenatide
If you are looking for an older GLP-1 peptide, exenatide is for you. Nevertheless, it needs a more frequent dosing. Here is a comparison.
Key Differences
| Feature | Exenatide | Semaglutide |
| User Experience | Often considered outdated | Modern and clean |
| Appetite Effects | Mild | Strong |
| Potency | Lower | High |
| Dosing | Twice daily. If you choose the extended release version, once weekly | Weekly |
What Do Biohackers Feel?
Many biohackers feel exenatide to be the least favored GLP-1 peptide, as nausea is commonly experienced. Also, it offers weaker appetite suppression and inconvenient dosing.
Semaglutide Vs. Tirzepatide
In reality, tirzepatide is not strictly a GLP-1 peptide. The reason is that it is a dual GLP-1/GIP agonist. As its effects are similar and just more intense, it comes up in this comparison. Here are the key differences:
| Features | Tirzepatide | Semaglutide |
| Mechanism | GLP-1 plus GIP Agonist | GLP-1 Agonist |
| GI Side Effects | Often slightly stronger | Common but manageable |
| Weight loss speed | Faster | Fast |
| Appetite suppression | Very strong | Strong |
Biohackers’ Take
Many biohackers consider tirzepatide to be the most powerful option presently. However, for those particular about a measured approach and for beginners, semaglutide is the go-to option. Once they understand how their body reacts, biohackers move from semaglutide to tirzepatide.
What Do Biohackers Consider When Selecting a GLP-1 Peptide?
Biohackers compare different factors when it comes to selecting a GLP-1 peptide. Here are a few of these factors:
- Appetite Suppression and Potency: Tirzepatide and Semaglutide rank the best.
- Convenience: When it comes to the convenience of taking and dosing frequency, weekly dosing is a big plus. Here, semaglutide wins
- Side Effect Profile: Some choose gentle GLP-1 peptides like Dulaglutide
- Weight-Loss Speed: Semaglutide wins by providing clinically proven, consistent, and long-term weight loss.
- Cost & Accessibility: Semaglutide might be costly, but it is worth the money you spend
- Goal Alignment:
- For beginner-friendly experimentation – Liraglutide
- For strong appetite control – Tirzepatide or Semaglutide
- For metabolic support – Liraglutide or Dulaglutide
Where Do Biohackers Get GLP-1 Peptides?
Biohackers look for providers that offer quick shipping across borders, secure ordering, third-party lab testing, and high purity. Here, platforms like CellPeptides.com are chosen by many biohackers in Europe and worldwide.
